Warning over long term COVID lung impact

A gound-breaking  study by university researchers has found that COVID suffers still have persistent damage to the lungs at least three months after being discharged from hospital.

The teams from the Universities of Oxford and Sheffield used a cutting-edge method of imaging to examine the lungs of patients which had been hospitalised with of COVID-19 and found long term impact from the disease.

This damage was not detected by routine CT scans and clinical tests, and the patients would consequently normally be told their lungs are normal.

Further early research by the team found that patients who had not been hospitalised with COVID-19 but who were experiencing long-term breathlessness may have similar damage in their lungs, but it would require a larger study to confirm their fears.

The study’s Principal Investigator Professor Fergus Gleeson, Professor of Radiology in the Department of Oncology, (University of Oxford) and Consultant Radiologist at Oxford University Hospitals (OUH) NHS Foundation Trust, said: “Many COVID-19 patients are still experiencing breathlessness several months after being discharged from hospital, despite their CT scans indicating that their lungs are functioning normally.

“Our follow-up scans using hyperpolarised xenon MRI have found that abnormalities not normally visible on regular scans are indeed present, and these abnormalities are preventing oxygen getting into the bloodstream as it should in all parts of the lungs.”

In the paper the researchers said that hyperpolarised xenon MRI (XeMRI) scans had found abnormalities in the lungs of some COVID-19 patients more than three months – and in some cases, nine months – after leaving hospital, when other clinical measurements were normal.

Professor Jim Wild, Head of Imaging and NIHR Research Professor of Magnetic Resonance at the University of Sheffield, said: “The findings of the study are very interesting. The 129Xe MRI is pinpointing the parts of the lung where the physiology of oxygen uptake is impaired due to long standing effects of COVID-19 on the lungs, even though they often look normal on CT scans.

“It is great to see the imaging technology we have developed rolled out in other clinical centres, working with our collaborators in Oxford on such a timely and clinically important study sets a real precedent for multi-centre research and NHS diagnostic scanning with 129Xe MRI in the UK.”

The study, which is supported by the NIHR Oxford Biomedical Research Centre (BRC), has now begun testing patients who were not hospitalised with COVID-19 but who have been attending long COVID clinics.

Gleeson added: “Although we are currently only talking about early findings, the XeMRI scans of non-hospitalised patients who are breathless – and 70% of our local patients with Long COVID do experience breathlessness – may have similar abnormalities in their lungs. We need a larger study to identify how common this is and how long it will take to get better.”

“We have some way to go before fully comprehending the nature of the lung impairment that follows a COVID-19 infection,” he added. “But these findings, which are the product of a clinical-academic collaboration between Oxford and Sheffield, are an important step on the path to understanding the biological basis of long COVID and that in turn will help us to develop more effective therapies.”

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